The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage

Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs.Despite extensive studies of the well-folding domains hfcs1lp responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) remains elusive.PARN is

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Typhoon-Related Post-Traumatic Stress Disorder and Trauma Might Lead to Functional Integration Abnormalities in Intra- and Inter-Resting State Networks: a Resting-State Fmri Independent Component Analysis

Background/Aims: Functional connectivity studies based on region of interest approach suggest altered functional connectivity of the default mode network (DMN), executive control network (ECN), and salience network (SN).The aim of this study is to determine whether intranetwork and internetwork brain connectivity are altered in both post-traumatic

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